R.O.A.R. stands for replication of ALS reversals. In this program, we will be conducting small pilot trials of treatments associated with ALS reversals. In response to feedback from patients, these trials will be widely inclusive, largely virtual (few in-person visits required), historically controlled (no placebos), and have results available in real-time. We will also publish our active protocols so that people outside the trials can discuss trying them with input from their own doctors.